{"id":9640,"date":"2022-06-08T11:05:48","date_gmt":"2022-06-08T10:05:48","guid":{"rendered":"https:\/\/www.x4lifesciences.com\/2022\/06\/08\/can-biological-signs-of-life-be-reversed\/"},"modified":"2022-07-12T09:50:40","modified_gmt":"2022-07-12T08:50:40","slug":"can-biological-signs-of-life-be-reversed","status":"publish","type":"post","link":"https:\/\/www.x4lifesciences.com\/de\/2022\/06\/08\/can-biological-signs-of-life-be-reversed\/","title":{"rendered":"Can biological signs of life be reversed?"},"content":{"rendered":"

[vc_row full_width=“stretch_row“ el_class=“dark“][vc_column][vc_column_text]<\/p>\n

Marks of Life<\/strong><\/h5>\n

A recent study published by\u00a0Aging Cell<\/a>, found that biological age can be reversed through the use of a drug \u2018cocktail\u2019 containing hormone medications. The study involved 9 healthy men between the ages of 41 and 55 taking the medication a few times a week for 1 year. The study found that on average patients experienced a reversed biological age of 2.5 years.<\/p>\n

Aging Cell commented that to their knowledge it is \u2018\u2019the first report of an increase, based on an epigenetic age estimator, in predicted human lifespan by means of a currently accessible aging intervention.\u2019\u2019<\/p>\n

Biological age can be predicted by \u2018epigenetic clocks\u2019 which scan the DNA and determine the biological age, by picking up chemical tags formed throughout the DNA strands. These chemical tags form almost like a barcode, allowing the biological age to be predicted within a range of about 2-3 years.<\/p>\n

The study however, according to lead author Gregory Fahy, wasn\u2019t intended to reverse biological age, but to prevent the shrinking of the thymus gland, which continually deteriorates as humans get older. This is the organ responsible for preventing various pathogens from entering the immune system.<\/p>\n

Fahy undertook his\u00a0own solo trial<\/a> in the early 2000s, which initially attempted to enlarge the thymus gland with similar growth hormones. Although evidence of re-growth was identified, the more recent study replicated the effects with a larger cohort, and to reveal if a group of self-administered growth hormones could replicate the regeneration of the gland \u2013 the study seemingly exceeded these initial expectations.<\/p>\n

[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=“stretch_row“ el_class=“light“][vc_column][vc_column_text]<\/p>\n

\n

Rewinding the Clock<\/strong><\/h5>\n<\/p>\n

Metformin, a drug commonly prescribed for its effects on diabetes and weight loss, is being tested by researchers for its potential in reversing common age-related diseases such as cardiovascular health and cancer. Fahy informs that the cocktail can have different effects on biological aging through various separate mechanisms in the respective drugs.<\/p>\n

Although this study seems to be groundbreaking in epigenetic sciences, Fahy acknowledges that \u2018\u2018this is a small study\u2019\u2019 which perhaps is the main concern behind these findings. A much larger study needs to be \u2018\u2018replicated with a larger more diverse group\u2019\u2019 says Fahy, with many fears of placebo effects or uncertainty over the pool\u2019s potential lifestyle changes which may have affected the findings.<\/p>\n

Regardless of the concerns around the conclusion, Sara Hagg, epidemiologist for the Karolina Institute in Sweden,\u00a0told Live Science<\/a>\u00a0\u2018\u2019the idea that biological age can be reversed is a highly interesting observation\u2019\u2019. In addition, cancer immunologist Sam Palmer at Hariot-Watt University in Edinburgh informed\u00a0Nature Magazine<\/a>\u00a0that this has \u2018\u2018huge implications not just for infectious disease but also for cancer and ageing in general\u2019\u2019.<\/p>\n

[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=“stretch_row“ el_class=“dark“][vc_column][vc_column_text]<\/p>\n

If you\u2019re a professional looking for a new opportunity in life sciences or have any questions about the market, then please don\u2019t hesitate to get in touch by emailing\u00a0info@x4lifesciences.co.uk<\/a>\u00a0or visiting our\u00a0jobs page<\/a>.[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row full_width=“stretch_row“ el_class=“dark“][vc_column][vc_column_text] Marks of Life A recent study published by\u00a0Aging Cell, found that biological age can be reversed through the use of a drug…<\/p>\n","protected":false},"author":1,"featured_media":9823,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[239,320],"tags":[],"class_list":["post-9640","post","type-post","status-publish","format-standard","hentry","category-insights","category-thought-leadership"],"yoast_head":"\nCan biological signs of life be reversed? - X4 Life Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.x4lifesciences.com\/2022\/06\/08\/can-biological-signs-of-life-be-reversed\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Can biological signs of life be reversed?\" \/>\n<meta property=\"og:description\" content=\"[vc_row full_width=“stretch_row“ el_class=“dark“][vc_column][vc_column_text] Marks of Life A recent study published by\u00a0Aging Cell, found that biological age can be reversed through the use of a drug...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.x4lifesciences.com\/2022\/06\/08\/can-biological-signs-of-life-be-reversed\/\" \/>\n<meta property=\"og:site_name\" content=\"X4 Life Sciences\" \/>\n<meta property=\"article:published_time\" content=\"2022-06-08T10:05:48+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-07-12T08:50:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.x4lifesciences.com\/wp-content\/uploads\/sites\/21\/2022\/06\/LS-Insights-Blog-Posts-8.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"655\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"x4group_cms\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"x4group_cms\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.x4lifesciences.com\\\/2022\\\/06\\\/08\\\/can-biological-signs-of-life-be-reversed\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.x4lifesciences.com\\\/2022\\\/06\\\/08\\\/can-biological-signs-of-life-be-reversed\\\/\"},\"author\":{\"name\":\"x4group_cms\",\"@id\":\"https:\\\/\\\/www.x4lifesciences.com\\\/#\\\/schema\\\/person\\\/7b98a0a3e9518ee1471a804ae06c7889\"},\"headline\":\"Can biological signs of life be reversed?\",\"datePublished\":\"2022-06-08T10:05:48+00:00\",\"dateModified\":\"2022-07-12T08:50:40+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.x4lifesciences.com\\\/2022\\\/06\\\/08\\\/can-biological-signs-of-life-be-reversed\\\/\"},\"wordCount\":546,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/www.x4lifesciences.com\\\/2022\\\/06\\\/08\\\/can-biological-signs-of-life-be-reversed\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.x4lifesciences.com\\\/wp-content\\\/uploads\\\/sites\\\/21\\\/2022\\\/06\\\/LS-Insights-Blog-Posts-8.jpg\",\"articleSection\":[\"Insights\",\"Thought Leadership\"],\"inLanguage\":\"de-DE\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.x4lifesciences.com\\\/2022\\\/06\\\/08\\\/can-biological-signs-of-life-be-reversed\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.x4lifesciences.com\\\/2022\\\/06\\\/08\\\/can-biological-signs-of-life-be-reversed\\\/\",\"url\":\"https:\\\/\\\/www.x4lifesciences.com\\\/2022\\\/06\\\/08\\\/can-biological-signs-of-life-be-reversed\\\/\",\"name\":\"Can biological signs of life be reversed? 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